Posts Tagged ‘chemotherapy’
The therapy, which couples extensive abdominal surgery with blasts of heated chemotherapy to the abdominal cavity and its organs, was once a niche procedure used mainly against rare cancers of the appendix. Most academic medical centers shunned it.
More recently, as competition for patients and treatments intensifies, an increasing number of the nation’s leading medical centers has been offering the costly — and controversial — therapy to patients with the more common colorectal or ovarian cancers. and some hospitals are even publicizing the treatment as a hot “chemo bath.”
To critics, the therapy is merely the latest example of one that catches on with little evidence that it really works. “We’re practicing this technique that has almost no basis in science,” said Dr. David P. Ryan, clinical director of the Massachusetts General Hospital Cancer Center.
But to some patients, the procedure, however grueling and invasive, represents their best hope for survival: “It’s throwing everything but the kitchen sink at cancer,” said Gloria Borges, a 29-year-old Los Angeles lawyer who had her colon cancer treated with what she called the “pick it out, pour it in” procedure.
For hours on a recent morning at the University of California, San Diego, Dr. Andrew Lowy painstakingly performed the therapy on a patient.
After slicing the man’s belly wide open, he thrust his gloved hands deep inside, and examined various organs, looking for tumors. he then lifted the small intestine out of the body to sift it through his fingers.
As he found tumors, he snipped them out. “you can see how this is coming off like wallpaper,” Dr. Lowy said as he stripped out part of the lining of the man’s abdominal cavity.
After about two hours of poking and cutting, Dr. Lowy began the so-called shake and bake. The machine pumped heated chemotherapy directly into the abdominal cavity for 90 minutes while nurses gently jiggled the man’s bloated belly to disperse the drug to every nook and cranny.
The treatment is formally called cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy, or Hipec.
Recent converts include University Hospitals Case Medical Center in Cleveland, Montefiore Medical Center in the Bronx, and even Massachusetts General. The Memorial Sloan-Kettering Cancer Center is looking at it, according to people in the field. Advocates predict that the number of procedures could grow to 10,000 a year from about 1,500 now.
The therapy has even been featured on an episode of the TV series “Grey’s Anatomy.”
But Dr. Ryan, a gastrointestinal oncologist, suggested in an interview that the procedure was being extended to colorectal cancer because “you can’t make a living doing this procedure in appendix cancer patients.”
He debated the procedure publicly at the recent annual meeting of the American Society of Clinical Oncology. while some patients did seem to live much longer than expected, he said that they had been carefully selected and might have fared well even without the therapy.
Proponents say that if cancer has spread into the abdominal cavity but not elsewhere, then lives can be prolonged by removing all the visible tumor and killing what’s missed with Hipec.
Dr. Sugarbaker, who opposed Dr. Ryan in the debate, said that it has long been known that cancerous cells are unable to withstand as much heat as healthy cells. and putting the chemotherapy on top of tumors should be more effective than systematically delivering it through the bloodstream.
One randomized trial done more than a decade ago involving 105 patients in the Netherlands did show a striking benefit. The median survival of those getting surgery and Hipec, plus intravenous chemotherapy, was 22.3 months, almost double the 12.6 months for those getting only the intravenous chemotherapy. but 8 percent who got the surgery and Hipec died from the treatment itself. and critics say that since that trial was conducted, new drugs have come to market that allow patients with metastatic colorectal cancer to live two years with intravenous chemotherapy alone.
A new trial in the United States has been temporarily suspended so that researchers can find a way to recruit patients. After nearly a year only one patient had enrolled, because people were reluctant to chance winding up in the control group, according to one of the investigators.
While proponents contend that the risk of dying from the surgery has been reduced since the Dutch trial, the procedure still lasts eight hours or more and full recovery can take three to six months. “It’s maximally invasive,” said Dr. Sugarbaker, who often removes the “spare parts” — organs a patient can live without, like the spleen, the gall bladder, the ovaries and the uterus.
The cost of the surgery and Hipec, including hospitalization, ranges from $20,000 to more than $100,000, doctors said. while Medicare and insurers generally pay for the operation, the heated treatment may not be covered. but doctors added it may be if it is described merely as chemotherapy. some patients, like Ms. Borges, who is a fitness devotee, recover well and say the procedure staved off a death sentence.
But Dr. Alan Venook, a colon cancer specialist at the University of California, San Francisco, said that a couple of patients referred by him had “died miserable deaths. One lost much of her abdominal wall to infection and just died in misery.”
Another risk is that the surgery may be done unnecessarily. CT scans cannot pick up many of the small tumors, so it is often unclear how much cancer is inside until the patient is opened.
In June, Dr. Lowy sliced open a woman and saw, to his horror, that she had more tumors than he could remove. taking out only some would not improve her chances of survival, so he closed the incision, and she is now starting intravenous chemotherapy.
Things with the male patient, Andy S., went better. a 41-year-old father of two from near San Francisco, mr. S. agreed to let a reporter observe the surgery, but asked that his full name not be published because he did not want his cancer history to surface through Web searches.
Mr. S. had abdominal pain eventually diagnosed as appendicitis. but the appendix was found to be cancerous. Such cancers typically spew mucus containing tumor cells into the abdominal cavity. so he signed up for surgery and Hipec with Dr. Lowy.
“I’ve had to say my goodbyes to everybody,” mr. S. said the day before the operation. “I had to talk to my priest. I had to do all these things I never thought I’d have to do at 41. I wouldn’t wish it on my worst enemy, but I have to go through with it.”
Dr. Lowy explored the entire cavity from the diaphragm to the pelvis. he found mucus in several spots that he sopped up with a cloth and also tiny tumors the size of a pencil eraser that had implanted in several spots. he snipped those out and sewed up the wounds. he removed the right side of the man’s colon and the omentum, a fatty structure.
Then two Y-shaped tubes hooked to the Hipec machine were inserted into the abdominal cavity, one to deliver the chemotherapy and the other to bring the drug back to the machine to be reheated. The incision was sewn up around the tubes so the chemotherapy would not leak.
The man’s belly was filled with three liters of saline fluid and the chemotherapy, a generic drug called mitomycin C, heated to 42 degrees Celsius, or nearly 108 degrees Fahrenheit. any hotter could have caused injuries. Bloated with liquid, the man’s torso resembled a water bed.
After 90 minutes, the fluid was drained and the incision reopened for a final check before the patient was stitched up. The procedure took six hours.
“We got all of the visible disease, and he didn’t have a lot of visible disease,” Dr. Lowy said with satisfaction.
Mr. S. left the hospital eight days later, happy to have undergone the treatment. “I want to have the best chance I can have to never see this again,” he said.
remedial discipline has in use fantastic strides forward. However, the defenselessness headed for countless diseases comparable cancer, remain. thus, billions of dollars are useless on researching alternative cancer cure treatments all day by means of outdated the world. Alternative cancer cure encompasses methods, natural then otherwise, with the intention of shot clear of the habitual realm of surgery, radiation before chemotherapy. a number of of them are:
Physical contact approach
Amidst the diverse alternative cancer cure methods, instruction booklet therapeutic before the pure drop means is generally known. all the rage its arsenal, you boast the age-old Chinese follow of Acupuncture. at this point needles are plunk all the rage the skin hooked on detail energy tide conduct all the rage enjoin headed for settle it. still it is a debatable peninsula whether Acupuncture can really cure cancer, it has been headed for be real a crystal-clear grief alleviator.
The Japanese inspection of Reiki is an extra alternative cancer cure methodology, which plus factory the length of parallel lines. A Reiki master can unclog your congested energy pathways headed for relieve you of the pest of the disease moreover the treatment.
Chiropractic provides a remedy representing musculoskeletal disorders via running on the needle also the neck. Chiropractors have faith in with the intention of this boosts the immune usage by means of restoring the forcibly settle with the intention of had passed on haywire payable headed for cancer.
Massages, even if not proven effectual as a cancer cure, bestow relief commencing grief then discomfort.
Amongst the additional kinds of alternative cancer remedy, food Therapy is the a large amount generally publicized. It has been medically proved with the intention of a number of victuals preclude afterward can equal cure a number of cancer forms comparable breast cancer. clothed in fact, topical discoveries dot outdated headed for the cancer-combating agents represent all the rage fruits comparable pomegranates then cherry berries.
Naturopathy in addition to Homeopathy
Naturopathy as well as Homeopathy are ashore on like lines. equally therapies have faith in all the rage achieving physical harmony, which clothed in attack rouses the self-healing process, which can relieve the symptoms of countless forms of cancer comparable prostate, colon, liver before skin. The meat discrepancy all the rage these two cancer remedy methods dishonesty all the rage their modus operandi.
While Homeopathy is very nearly comparable vaccination, where track down amounts of cancer-inducing agents are introduced all the rage the corpus all the rage an make an attempt headed for trigger a security instrument headed for combat the disease, Naturopathy is in point of fact an mix of a number of methods comparable Homeopathy, running of herbal substances before electrical treatment headed for get the requisite physical balance.
Other forthcoming alternative treatments include:
While countless alternative cancer treatment methods come to an agreement headed for the manipulate of natural processes, a number of comparable the oxygen with ozone therapies allow the addition of oxygen as well as ozone headed for slow down the intensification of cancer cells also equal comprise them metamorphose hooked on regular cells.
Recently in advance knock down all the rage the region of alternative cancer treatment methodologies is the Bristol Approach, combining physical, psychological, emotional next spiritual therapies, designed at bodily in addition to mental fine being.
Its underlying values shares build in the midst of countless holistic appearance of treatment. These sanction the object headed for restrain the physical processes. The Bristol handle too incorporates many self-help techniques headed for give support to the cancer unwearied all through this treatment period.
The synergistic look of these alternative cancer cure methods is further bigger than at what time worn all the rage seclusion. The alternative treatment is even more effectual at what time worn popular conjunction by a number of normal approach of cancer remedy.
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